FORMULATION AND EVALUATION NON-EFFERVESCENT FLOATING TABLET OF CAPTOPRIL USING COMBINATIONS OF POLYMER HPMC AND NA-CMC

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Published Jul 8, 2020
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Vol. 3 No. 04 (2020): International Journal of Medical Science in Clinical Research and Review

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Anggun Hari Kusumawati1, Iin Lidia Putama Mursal1, Neni Sri Gunarti1,Karina Risnawati1
Universitas Buana Perjuangan Karawang

Abstract

Captopril has a rapid elimination half-life for about 2-3 hours and degrades in the intestine. The pH increasing causes captopril to become unstable and degrades, so captopril suitable for floating tablet preparations. The preparation a floating tablet in this study used a combination of HPMC and CMC-Na polymers, where HPMC can control drug release and inhibit excessive erosion of tablets. While CMC-Na can be used to increase the viscosity of preparation so that it will take more time the drug to floats in the gastric. This study aims to determine the influence of the combination of HPMC and CMC-Na polymers against the physical properties and dissolution profiles of floating captopril tablets. The tablet was made by a wet granulation methods with a combination of HPMC and CMC-Na F1 (55%: 13%), F2 (50%: 18%), and F3 (45%: 23%). Test parameters that are used were hardness, friability, floating assay, and % dissolution. The result of the study was processed statistically with SPSS version 20. The results showed that the differences in the concentrations of HPMC and CMC-Na did not affect the friability, floating test, and % dissolution of the preparation. The results showed that the differences in the concentration of HPMC and CMC-Na affected the results of tablet hardness, the more concentrations of HPMC were used it would increase tablet hardness, and the more concentration of CMC-Na used would reduce tablet hardness. Comparison of 55% HPMC and 13% CMC-Na is the formulation with optimum % dissolution is 92.6543 % for 12 hours .

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Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Author Biography

Anggun Hari Kusumawati1, Iin Lidia Putama Mursal1, Neni Sri Gunarti1,Karina Risnawati1, Universitas Buana Perjuangan Karawang

1Faculty of Pharmacy, Buana Perjuangan Karawang University, Karawang, West Java, Indonesia 41361.

How to Cite
Neni Sri Gunarti1,Karina Risnawati1, A. H. K. I. L. P. M. (2020). FORMULATION AND EVALUATION NON-EFFERVESCENT FLOATING TABLET OF CAPTOPRIL USING COMBINATIONS OF POLYMER HPMC AND NA-CMC. International Journal of Medical Science in Clinical Research and Review, 3(04), Page : 127–133. Retrieved from https://ijmscrr.in/index.php/ijmscrr/article/view/98

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