Comparison Study Between Rosuvastatin and Hibiscus Sabdariffa to Alleviate Atherosclerosis in Male Rabbits

Abstract

Background:

Cardiovascular diseases (CVDs) are important causes of elevated healthcare costs and disability and premature death . A significant proportion of this morbidity and mortality can be  reduced by application a healthy system that includes health care and the use of effective treatments and great safety.

Objective:

This study aims to compare between hydroalcoholic extracts of  Hibiscus sabdariffa and rosuvastatin in mitigating cardiovascular damage induced experimentally in male New Zealand rabbits.

Materials and Methods:

Twenty eight male local rabbits were randomly divided into four equal groups. The first group served as the control (NCG), the second group was induced with positive atherosclerosis un treated, The III group (A therogenic group and Rosuvastatin 0.88 mg/kg. The IV group (atherogenic and 100 mg / kg of  Hibiscus sabdariffa Calyx  extract daily throughout the experiment. The treatment was persistent for six  weeks.

Results:

The study demonstrated that H. sabdariffa a significant enhancement in antioxidant activity (superoxide dismutase and catalase) and a reduction in levels cardiac enzyme (serum troponin I, LDL, CKMB, CRP and myoglobin). Additionally, the hawthorn extract led to clear reduction of total cholesterol ,    triglyceride ,VLDL, heart rate and  increased HDL. Moreover, Rosuvastatin appear improvement in among parameters with limited effect antioxidant activity. This study concluded that The extract of the H. sabdariffa plant has a role in protecting the heart from toxic effects by reducing cardiac enzymes, as well as increasing antioxidant factors, repairing heart cell tissue, and repairing damage to the blood vessel wall.