A Study of Leptin & Thyroid Hormones in Pre and Post-Operative Patients with Thyrotoxicosis

Abstract

Background:

Hyperthyroidism is a thyroid hyperfunction. Treatment options include: Anti thyroid drugs, radioiodine therapy, and / or thyroid surgery. Leptin is a peptide hormone considered to play a role in the maintenance of energy balance and body weight by neuroendocrine mechanism. Thyroid hormones also take part in energy metabolism and have marked effects on adipose lipid metabolism. However it is not known whether adrenergic receptors or TSH receptors on adipocytes may play a role in regulating this hormone secretion from adipocytes.

Objective: to look for the functional relationship between leptin, TSH and thyroid hormones in pre and post-operative patients with thyrotoxicosis.

Patients and Methods: A total number of 78 samples divided into: Control group (n= 26) Pre-operative group (n= 26) Postoperative group (n= 26). For all studied Patients measurement of fasting serum leptin, thyroid hormones, (T3, T4, TSH) lipid profile and their BMI had been done.

Results: Mean serum leptin level was significantly increased post-operatively Compared to pre-operative group (p<0.05) while the thyroid hormones (T3, T4, TSH) returned to normal levels post-operatively (p<0.05), lipid profile was significantly increased postoperatively ( p<0.05) while BMI not significantly changed in two groups (p>0.05).

Conclusions: leptin has a strong functional relationship with thyroid hormones (T3, T4, TSH) in pre and post-operative patients with thyrotoxicosis while their lipid profile increased post-operatively irrespective to their BML.

Keywords: Leptin, Thyroid Hormones, Thyrotoxicosis