A Prospective Study of Serum Ferritin Level in Vector Born Disease

Abstract

Abstract

Introduction: Present work was conducted to study serum ferritin level in vector born disease and find out the change from day 1 to day 5 and to assess changes in serum ferritin level or the course of illness of vector born disease at day 1 and day 5 to establish its utility as a prognostic marker.

Methodology: A hospital based prospective observational study was conducted in Department of Medicine, S R.N.T. Medical College and M.B.G.H. Udaipur. A sample size of 140 was taken with inclusion criteria: suspected vector born disease with history of fever and age more than 18 year. Exclusion criteria: Patients with underlying malignancy, septicemia, Chronic kidney disease, liver disease, any autoimmune disorder, IBD, obesity (BMI >30 kg/m²), hyperthyroidism, extreme physical activity, respiratory infection etc and did not giving consent.

Results: The mean (SD) age of study participants was 38.6 (16.8) years with 75 were female and 65 were male participants. Maximum (62 patients) were in age group of 20-40 years followed by 43 patients in 41-60 years. We found that mean ferritin level in malaria patients was significantly decrease on day 5 compare to day 1. Similarly, Ferritin level was decreased from day 1 to day 5 but it was statistically insignificant. And, also in scrub typhus Ferritin level was decreased from day 1 to day 5 but it was statistically insignificant. We also found that patients that were serious ill serum ferritin level was significantly high on day 1 and day 5 compare to rest of the patients.

Conclusion: Our study concluded that serum ferritin level can be used as an inflammatory marker in vector borne diseases and it also predicts the severity of vector borne diseases.