STUDY OF A STROMAL MARKER CD 10 IN INVASIVE BREAST CARCINOMAS AND ITS CORELATION WITH PROGNOSTIC FACTORS

Abstract

Introduction: Breast carcinoma is the most common cancer among women with no regional variations and the second most common cancer worldwide. It accounts for an estimated 167,000cases/year (2012) worldwide. It is the fifth leading cause of cancer death worldwide accounting for 522,000 deaths/year (2012). It also tops the list of cancer death among women, living in underdeveloped countries. CD10 (common acute lymphoblastic leukaemia antigen, CALLA) is a cell surface zinc dependent protease. CD10 acts as a stem cell regulator in the breast and prevents uncontrolled proliferation of stem cells. It is expressed in breast myoepithelial cells, lymphoid stem cells, neutrophils, and other epithelial cells. CD10 is also expressed in stroma of prostate, lung and colorectal cancers. Methodology: Brief clinical details of the patient such as age, gender, clinical diagnosis and surgical procedure was collected from the requisition form. All these surgical specimens were fixed in 10% buffered formalin, routinely processed, paraffin-embedded and stained with haematoxylin and eosin stain. The cases which were diagnosed as breast specimens with Infiltrating ductal carcinoma, NOS and its variants in Haematoxylin and Eosin stain were analysed and immunohistochemical marker CD10 were performed. With the results statistical analysis were done to corelate the positive cases with the prognostic factors. Result: This study was carried out in the department of pathology, Sri Venkateshwaraa Medical College and Research Centre, Puducherry in collaboration with the department of General Surgery. Total of 60 patients were included in our study. On comparing CD 10 positivity among invasive breast cancers with age , tumor size and nodal metastasis the following results were observed

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  Age is not correlating with the CD10

  
  


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  Tumour size does not correlate with the CD 10 marker positivity. Also in most of the studies there is no correlation between CD10 positivity and tumour

  
  


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  The presence of lymph node metastasis is not correlating with CD10 marker positivity

  
  

     The study can be further continued with other prognostic markers with more sample size as a future scope.