ASSESSMENT OF PATTERN OF ADVERSE DRUG REACTIONS FROM ANTI-CANCER DRUGS IN A TERTIARY CARE HOSPITAL: A CROSS-SECTIONAL STUDY

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Published Aug 31, 2022
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Vol. 5 No. 04 (2022): International Journal of Medical Science in Clinical Research and Review

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Dr Ruchi Mathur
Mahatma Gandhi Medical College and Hospital, Jaipur
Dr Anusha Vohra
Dr Shipra Jain
Dr Hemant Malhotra

Abstract

BACKGROUND: Chemotherapy is one of the multimodal approaches to the treatment of cancer and adverse drug reactions (ADRs) are very commonly related with these anti-cancer agents. The present study is done with the aim to assess the pattern of adverse drug reactions due to anti-cancer therapy, analyse their causality and severity, and assess the pattern of drugs used for the treatment of adverse drug reactions.


MATERIALS AND METHODS:  A cross-sectional study was conducted at a tertiary care teaching hospital for one year after obtaining approval from the ethics committee. All the cancer patients of either sex with age >18 years, admitted in the oncology department were included in the study. A pre-designed proforma was used for filling demographic, clinical, and prescribing details of the patient. Causality and severity of adverse drug reactions were assessed by using the WHO-UMC causality scale and Modified Hartwig and Seigel severity scale, respectively.


RESULTS: Out of 126 cancer patients enrolled in the study, 65% were females while 35% were males. The majority (30%) of the total study participants were in the age group of 51-60 years. A total of 259 ADRs were observed in cancer patients. 83% of the total ADRs were probable/likely in causality and 74% were mild ADRs. It was observed that fatigue, weakness, and dizziness were the most commonly occurring ADRs for which multivitamins were prescribed. The most common class of drug implicated in causing ADRs was Platinum coordination complex.


CONCLUSION: ADR monitoring is needed with anti-cancer drug management, to increase patient compliance and decrease hospital stay. Management of ADRs beforehand will help in reducing the suffering of patients and increase compliance. ADR monitoring is the need of the hour especially in cancer patients in order to increase patient compliance and decrease morbidity.


KEYWORDS: ADRs, Anti-cancer agents, Pharmacovigilance, Management of ADRs, Causality, Severity.

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How to Cite
Mathur, D. R., Vohra, D. A., Jain, D. S., & Malhotra, D. H. (2022). ASSESSMENT OF PATTERN OF ADVERSE DRUG REACTIONS FROM ANTI-CANCER DRUGS IN A TERTIARY CARE HOSPITAL: A CROSS-SECTIONAL STUDY. International Journal of Medical Science in Clinical Research and Review, 5(04), Page: 263–268. Retrieved from https://ijmscrr.in/index.php/ijmscrr/article/view/221

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