CORRELATION OF THYROID PROFILE WITH GAMMA-GLUTAMYLTRANSFERASE IN PATIENTS WITH LIVERCIRRHOSIS

Abstract

Introduction: Cirrhosis is a condition in which the liver slowly deteriorates and fails to function properly due to chronic injury. It is an increasing cause of morbidity and mortality in most developed countries. thyroid profile consists of triiodothyronine(T₃), thyroxine (T₄), and Thyroid Stimulating Hormone (TSH). Only 20% of circulating T₃is synthesized in the gland and the rest is generated by T₄in the liver. Gamma-Glutamyltransferase (GGT) is a dimericglycoproteinandiseffectiveinthediagnosisofLiverDiseases.

Aim: To evaluate the correlation of Thyroid profile with Gamma-Glutamyl Transferase inLiverCirrhosispatients.

Materials and Methods: 100 clinically diagnosed cases of Liver Cirrhosis patientsagedbetween30-65yearsofeithergenderwereenrolledinthestudy.Patientswithpriorhistoryof

thyroid disease, undergoing thyroid medications and with other chronic disease were excluded. Blood samples were drawn from enrolled patients and estimation of thyroid profileandGGTwasdonetoassessthecorrelationbetweenthem by applying statistic evaluation.

Results: A strong negative correlation between T₃and GGT (r-value= -0.3105 and p-value=0.002)inlivercirrhosispatientswas observed.

Conclusion: The present study suggested a strong negative correlation between T₃and GGTin patients of Liver Cirrhosis. Therefore, serum T₃ levels in association with serum GGT can be a useful marker for the early prognosis of Liver Cirrhosis and can be helpful in better management of patients at risk and in averting the risk of progression to Cirrhosis, End StageLiver                      Disease                                and            Hepatocellular                              Carcinoma