FORMULATION AND EVALUATION OF NIOSOMAL GEL CONTAINING TAZAROTENE FOR THE TREATMENT OF ACNE AND PSORIASIS
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Abstract
Psoriasis is a chronic inflammatory skin disorder that may drastically affect the quality of life of an affected person. Different treatments are available for psoriasis and among this topical therapy are most commonly used in majority of patients. Tazarotene is a prescription topical retinoid sold as a cream or gel. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). This compound belongs to the class of organic compounds known as retinoids. In Present study aimed to develop niosomal gel for the treatment of acne and psoriasis. The release of the drug in the deep layers of the skin and its transdermal absorption could then be the result of a fusion of niosomes, with skin lipids and drug release at various points along the penetration pathway. It can be concluded that a gel formulation containing niosomes loaded with Tazarotene showed prolonged action and it can be developed successfully to improve the dermal infections.
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