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<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.0" xml:lang="en">

<front>
<journal-meta>
<journal-title-group>
<journal-title>International Journal of Medical Science in Clinical Research &amp; Review</journal-title>
</journal-title-group>
<issn pub-type="epub">2581-8945</issn>
</journal-meta>

<article-meta>

<article-id pub-id-type="doi">10.5281/zenodo.18897740</article-id>

<title-group>
<article-title>Evaluating the rapid onset of analgesic efficacy of a novel calcium fructoborate complex (BRAVOFLEX®) in subjects with knee discomfort: A clinical analysis</article-title>
</title-group>

<contrib-group>
<contrib contrib-type="author">
<name>
<string-name>Zahid Sipai, Dr. Javed Sipai</string-name>
</name>
<xref ref-type="aff" rid="aff-1"/>
</contrib>
</contrib-group>

<aff id="aff-1">R&amp;D Division, Aurora Farmabio Pvt Ltd.</aff>

<pub-date iso-8601-date="2026-03-7">
<day>7</day>
<month>03</month>
<year>2026</year>
</pub-date>

<self-uri xlink:href="https://ijmscrr.in/index.php/ijmscrr/article/view/1350"/>

<abstract>
<p>The clinical management of joint discomfort typically involves long-term administration of glucosamine or chondroitin, which often require 8–12 weeks for therapeutic onset [1]. This paper evaluates the clinical efficacy of Bravoflex®, a nature-identical Calcium Fructoborate (CFB) complex. In a standardized clinical observation (Study 1), subjects with mild-to-moderate knee discomfort were administered 110 mg of Bravoflex® twice daily. Results demonstrated a statistically significant reduction in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores within 7 to 14 days, positioning Bravoflex® as a high-bioavailability alternative for rapid joint mobility restoration.

Keywords: Calcium Fructoborate, Bravoflex®, Joint Pain, WOMAC, Boron-Carbohydrate Complex, Rapid Onset.</p>
</abstract>

</article-meta>
</front>

</article>