A Study on Sildenafil Citrate in the treatment of IUGR & Oligohydramnios
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Abstract
Intra Uterine Growth Restriction is a challenge to clinicians all over the world because no definitive treatment is available and many empirical therapies are tried for treating the same. The present study was a multi-centric hospital based prospective observational study conducted in three tertiary care centres in Northern India on 200 patients with late onset IUGR and oligohydramnios. Sildenafil citrate 25 mg 8 hourly was given till delivery. All the outcomes were noted and analysed. After sildenafil therapy, 87 out 0f 90 patients with only IUGR, 35 out of 40 cases of oligohydramnios only and 64 out of 70 patients with IUGR & oligohydramnios both had marked improvement & 14 cases showed no improvement. From this study we concluded that adding sildenafil citrate in the treatment of IUGR and oligohydramnios can be a beneficial option.
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References
-
1. P. Joshi et al-Role of sildenafil in Fetal Growth Restriction from N, India. Int. J. Reprod. Contracept. Obstet. Gynecol. 2019;8:165-168
2. Sharma M.S. et al- Intrauterine growth retardation.J Neonatal Biol. 2014;3(135):167-897
3. Froen JF et al . Restricted Fetal Growth in sudden intrauterine unexplained death.Acta Obstet Gynecol Scand.2004; 83(9):801-7
4. Richardus et al . Differences in perinatal mortality and suboptimal care between 10 European regions .BJOG 2003;110(2):97-105
5. Peterson et al . Early onset, severe FGR with absent or reversed end-diastolic flow velocity waveform in the umbilical artery : perinatal and long term outcomes. Aust NZ ObstetGynecol 2009;49(!):45-51
6. Bilardo CM et al. Relationship between parameters and outcome in severe early onset IUGR. Ultrasound Obstet Gynecol 2014;23(2):119-125
7. Olofsson et al . A high uterine artery pulsatility index reflects a defective development of placental bed spiral arteries in hypertension in pregnancy and FGR.Eur J ObstetGynecolReprodBiol . 2003; 49(3):161-168
8. Sagol S et al . Placental villus vascularization and its relation to umbilical artery Doppler flow in IUGR.PrenatDiagn. 2002;22(5):398-403
9. Von D et al . Sildenafil therapy in severe early onset IUGR .BJOG.Int. J Obstet Gynecol . 2011;118(5):624-8
10. Dastjerdi MV et al. Sildenafil citrate and uteroplacental perfusion in FGR.J. Res Med Sci. 2012;17(7):632-636
11. Dunn L et al. A systemic review: Sildenafil citrate in pregnancy. FetDiagnos Ther.2017;41(2):81-88
12. Miller SL et al.The effects of sildenafil citrate on uterine blood flow and wellbeing in IUGR fetus. Am J Obstet Gynecol . 2009; 200(1):102 โel
13. Maged M et al. Use of sildenafil citrate in cases of IUGR; a prospective trial. Taiwanese J Obstet Gynecol.2018;57(4):483-6
14. Premlatha HL et al. Study of effect of sildenafil citrate in pregnancy with IUGR.Int J ReprodobstetGynecol .2016;5(9):3094-7
15. Singh A et al.Effect of Sildenafil citrate on IUGR.Int J ReprodContracept Gynecol. 2017;6(5):1806-9
16. Panda et al โ Sildenafil citrate in FGR. J.Reprod. Infertil. 2014;15(3):168-169
17. Ferreira E et al. Sildenafil use during pregnancy for IUGR :A case series. J Obstet. Gynecol. Canada.2016;38(5):486-88