Propofol Safety in Pediatric Surgery: A Comprehensive Review

Abstract

Propofol, a widely used intravenous anesthetic agent, has gained widespread acceptance due to its favorable pharmacokinetic and pharmacodynamic profile. In pediatric anesthesia, it offers rapid induction, smooth recovery, and a lower incidence of postoperative nausea and vomiting. Despite these advantages, concerns persist about its safety, particularly regarding potential neurotoxicity in developing brains, hemodynamic instability, and propofol infusion syndrome (PRIS). This article reviews the current evidence on propofol safety in pediatric surgery, focusing on its pharmacology, benefits, risks, and guidelines for safe use in the pediatric population.

Keywords: Propofol, pediatric surgery, anesthetic agent