Efficiency of 5 fluorouracil solution application using dermaroller in the treatment of vitiligo

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Published Jun 20, 2020
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Vol. 3 No. 03 , (2020): International Journal Of Medical Science in Clinical Research and Review

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Vasileva Mirela1, Mirova Shakleva Elena2, Petrovski Dejan3, Gordana Lazarova2, Petrovska Noveska Biljana4, Brishkoska Boshkovski Vesna5, Dimitrovska Irena5
1Department of dermatology - Clinical hospital Shtip, Republic of Macedonia, 2University Goce Delchev, Shtip Republic of Macedonia, 3Department of dermatology - Clinical hospital “Dr Trifun Panovski” Bitola, 4Department of pathology - City general hospital “8th September” Skopje, Republic of Macedonia, 5Department of dermatology - City general hospital “8th September” Skopje, Republic of Macedonia

Abstract

Introduction: Vitiligo is a common acquired condition, resulting from the progressive loss of melanocytes (1). Vitiligo affects 0.5–1 % of the world’s population, It can appear at any age. The prevalence is probably the same in sexes, but higher prevalence is suggested  in dark-skinned individuals (1,2).  Vitiligo Is a major dermatologic challenge considering the many available therapeutic modalities (5). Case report: We present two patients who were treated with 5FU and microneedling using a dermaroller over a period of 3 months. Both patients are in their 3rd decade of life, diagnosed with vitiligo several years ago. The treated lesions were stable and unchanged over time. We present the results of the treatment together with the pathohistological finding of treated and untreated lesions. Conclusion: After needling and application of topical 5-fluorouracil, patohistology report shows a strong inflammatory reaction and minor edema. New promising therapeutic modalitie is topical 5-fluorouracil (5-FU), which probably stimulates  repigmentation in vitiligo by direct over stimulation of proliferation of the melanocytes and an increase in the number of melanosomes in the keratinocytes.


 


Keywords: Microneedling, 5-fluorouracil, repigmentation, vitiligo

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How to Cite
Vasileva Mirela1, Mirova Shakleva Elena2, Petrovski Dejan3, Gordana Lazarova2, Petrovska Noveska Biljana4, Brishkoska Boshkovski Vesna5, Dimitrovska Irena5. (2020). Efficiency of 5 fluorouracil solution application using dermaroller in the treatment of vitiligo. International Journal of Medical Science in Clinical Research and Review, 3(03 ,), Page: 100–104. Retrieved from http://ijmscrr.in/index.php/ijmscrr/article/view/89

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