Association between a Naso Pharyngeal Carcinoma and other Cancers

Abstract

Introduction: The advent of a cancer is a tragedy for the patient, family and for society as a whole. What does one say when the occurrence of 2 consecutive cancer? Objective of study: is to research a relationship between Epstein Barr Virus (EBV) and other cancer associated with nasopharyngeal cancer. Materials and Methods: Our study is   retrospective   from 2021 to 2023   .We collected 5 patients 3 Male / 2 Female   with a sex ratio = 1.5   .All   patients had nasopharyngeal cancer. The average age at first cancer diagnosis is 46 years (30-65) Revealing signs of nasopharyngeal cancer were node cervical in 80%, ear signs in   80%, rhinologic signs in 80% and neurological signs in 15%.   Associated cancers were, Breast cancer: 2 cases. Hodgkin's disease: 2 cases. Adenocarcinoma of prostate: 1 case. The average age at diagnosis of second cancer is 48 years (31-66  ). The average time between onsets of cancer is 2 to 16 months (14-28). 20% patients has a family history for malignant neoplasms (Breast cancer and NPC) All patients had a positive EBV Serology. Results: we look for LMP1 in  Tumor Biopsies with  Immunohisto chemistry. LMP1 was found in  all NPC (100%)   , in one Breast cancer (1/2) and it was negative in Hodgkin's lymphoma (0/2)  and  prostate cancer ( n=0/1 ) Conclusion: The role of Epstein-Barr virus in the genesis of cancer associated with nasopharyngeal cancer is not yet established and deserves further research.

Keywords: Naso Pharyngeal Carcinoma, Other cancer, Epstein Barr Virus.