Curcumin present in plants reduces both the oxidation and circulation of oxidized levels of LDL cholesterol

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Published Mar 17, 2020
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Vol. 3 No. 02 , (2020): International Journal of Medical Science in Clinical Research and Review

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Shumaila Najeeb, Shah Murad Mastoi Baloch, Nusratullah Khan, Hafiz Moeen-Ud-Din, Seema Shah Murad, Farid-Ud-Din, Seema Shah Murad
Asso Prof of Histopathology at Yusra Medical College, Islamabad Pakistan Professor of Pharmacology, IMDC, Islamabad, Pakistan. Assistant Prof of Biochemistry at Bolan University of Medical and health Sciences, Quetta, Pakistan Associate Prof of Anatomy at KEMU, Lahore Pakistan Gynecologist at NMC Karachi Pakistan Lecturer Pharmacology at IMD and DANTH Islamabad Pakistan Gynecologist at IMDC, Islamabad Pakistan

Abstract

In the body, liver produces approximately 80% of the cholesterol whereas rest of the cholesterol is obtained from the food like fish, eggs, meat, etc. After having a meal, cholesterol is digested and absorbed in small intestine then the metabolism and storage occurred in the liver. The cholesterol may be secreted by the liver whenever the requirement of cholesterol is needed by the body. Cholesterol is not present in the food which is derived from the plants. We in this study have compared hypolipidemic effects of Fenugreek, Curcuma longa, and Lemon. Study was conducted at Jinnah Hospital Lahore-Pakistan from January 2018 to May 2018. Ninety hyperlipidemic patients of age group 19 to 70 were included in the study. Exclusion criteria were diabetic, alcoholic additives, hypertensive patients and those whose kidney or liver functions were impaired. Consent was taken from all participants. Their base line lipid profile was taken in biochemistry laboratory of the hospital.   They were divided in three groups i.e. 30 patients in each group. Group-I was advised to take 500 mg of Curcuma longa (haldi) mixed in fresh milk without cream, thrice daily for two months. Group-II patients were advised to take 100 grams of Fenugreek leaves mixed with salad in each meal (thrice daily) for the period of two months. Group-III patients were advised to take 40 ml of fresh lemon juice mixed with 40 ml mineral water thrice daily for two months. They all were advised not to take heavy meal rich with any type of fat like junk food etc. One hour daily brisk walk was advised to all participants. 15 days follow up visit was scheduled for them. After two months their lipid profile was re-determined. When results were compiled and statistically analyzed by applying paired ‘t’ test, it revealed that Curcuma longa decreased total cholesterol, TG, LDL cholesterol 16.10, 20.01, and 17.59 mg/dl respectively. Fenugreek decreased total cholesterol, TGs, and LDL cholesterol 14.70, 17.33, and 17.06 mg/dl respectively. Lemon in two months therapy decreased total cholesterol, TGs, and LDL cholesterol 15.45, 10.13, and 11.97 mg/dl respectively. None of the above mentioned herbs raised HDL cholesterol significantly. It was concluded from this research work that Curcuma longa, Fenugreek leaves and Lemon are mild to moderately effective hypolipidemic herbs to lower total plasma cholesterol, triglycerides, and LDL cholesterol but have no potential to raise HDL cholesterol when analyzed biostatistically. KEY WORDS: Lemon, Methi, Haldi, Plants, Hyperlipidemia, CAD, Prevention and Cure

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Author Biography

Shumaila Najeeb, Shah Murad Mastoi Baloch, Nusratullah Khan, Hafiz Moeen-Ud-Din, Seema Shah Murad, Farid-Ud-Din, Seema Shah Murad, Asso Prof of Histopathology at Yusra Medical College, Islamabad Pakistan Professor of Pharmacology, IMDC, Islamabad, Pakistan. Assistant Prof of Biochemistry at Bolan University of Medical and health Sciences, Quetta, Pakistan Associate Prof of Anatomy at KEMU, Lahore Pakistan Gynecologist at NMC Karachi Pakistan Lecturer Pharmacology at IMD and DANTH Islamabad Pakistan Gynecologist at IMDC, Islamabad Pakistan

Shumaila Najeeb, Asso Prof of Histopathology at Yusra Medical College, Islamabad Pakistan

Shah Murad Mastoi Baloch, Professor of Pharmacology, IMDC, Islamabad, Pakistan.

Nusratullah Khan, Assistant Prof of Biochemistry at Bolan University of Medical and health Sciences, Quetta, Pakistan

Hafiz Moeen-Ud-Din, Associate Prof of Anatomy at KEMU, Lahore Pakistan

Seema Shah Murad, Gynecologist at NMC Karachi Pakistan

Farid-Ud-Din, Lecturer Pharmacology at IMD and DANTH Islamabad Pakistan

Seema Shah Murad, Gynecologist at IMDC, Islamabad Pakistan

How to Cite
Shumaila Najeeb, Shah Murad Mastoi Baloch, Nusratullah Khan, Hafiz Moeen-Ud-Din, Seema Shah Murad, Farid-Ud-Din, Seema Shah Murad. (2020). Curcumin present in plants reduces both the oxidation and circulation of oxidized levels of LDL cholesterol. International Journal of Medical Science in Clinical Research and Review, 3(02 ,), Page : 29–34. Retrieved from http://ijmscrr.in/index.php/ijmscrr/article/view/73

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