Recent Advances in Dermatology Semisolid Dosage Forms

Abstract

Pharmaceutical semisolid preparations contain ointments, pastes, cream, emulsion, gels, and rigid foam. They act as carriers for drugs that are distributed topically via the skin, cornea, rectal tissue, nasal mucosa, vagina, buccal tissue, urethral membrane, and outer ear lining. Semisolids can cling to the application surface for long sufficient periods until it is washed off. This property helps to extend the distribution of drug at the site of application. Novel semisolids are non-greasy since they consist of washable water bases. Therefore, they cause less inflammation and are superior to the traditional method of semisolid dosing. The present innovation of semisolids involves choosing an effective drug carrier system with particular focus on physicochemical properties and required therapeutic application. This article reviews the recent advances of topical dermal semisolids and its evaluation.

Keywords: Topical semisolids, hydrogels, Rheological behaviour, drug delivery system, nanoemulsions