Synchronous Malignancy of Olfactory Neuroblastoma And Carcinoma Breast

Abstract

Olfactory Neuroblastoma is a malignant neuroectodermal neoplasm arising from the olfactory membrane/olfactory placode of the sinonasal tract. It is an uncommon malignant neoplasm comprising 3% of all sinonasal tumours. Annual incidence of 4 cases/10 million population, occurs mostly between 5th to 6th decade of age. We report a case of 28 year old female patient presented with spontaneous episode of epistaxis. On histopathology showed uniform round cells with vesicular nuclei and indistinct borders surrounded by neurofibrillary material and few pseudorosettes. During the follow up period, patient was diagnosed with invasive breast carcinoma (within 3 months).

Keywords: olfactory neuroblastoma, olfactory placode, sinonasal tumours