The Relationship Between Grace Risk Score and Glucose Fluctuation in Patients with Acute Coronary Syndrome and Abnormal Glucose Metabolism Using Continuous Glucose Monitoring System.

Abstract

Background: Acute coronary syndrome is an important global cause of death and also the major cause of morbidity and mortality in India. The importance of glucose metabolism in patients with “acute coronary syndrome” has been increasingly recognized.

Aims: To determine the association between grace risk score and glucose fluctuation in patients with acute coronary syndrome and abnormal glucose metabolism using Continuous Glucose Monitoring System.

Materials & Methods: Prospective Cohort Study conducted for a period of 18 months from January 2019 to June 2020

Results: A total of 77 participants were included in the study. The mean age of the participants was identified as 52.31 ± 7.9. Majority of the participants were belonged to killip class II with 58.44%. Elevated Cardiac Enzymes and ST Deviation were identified in 55.84% and 44.16% of participants. The mean Grace risk score and mean 24 Hours Mean Blood Glucose (mmol/l) were 129.35 ± 31.15 and 9.67 ± 3.28. Majority of the participants were belonged to the high-risk group with 35.06%. The median 24 hours mean blood glucose (mmol/l) in low risk, moderate and high risk were 6.32 (IQR 6.03 to 8.5), 9.08 (IQR 7.983 to 9.93) and 11.3 (IQR 10.16 to 13.8) respectively.

Conclusion: High prevalence of abnormal glucose metabolism was found in ACS patients. Higher blood glucose fluctuation is associated with moderate and high GRACE risk scores in patients with ACS and abnormal glucose metabolism.

Keywords: Grace Risk Score, Fluctuation, Acute Coronary Syndrome, Abnormal Glucose Metabolism