TREATMENT OF INCOMPLETE AND MISSED ABORTION WITH ORAL MISOPROSTOL

Abstract

Medical termination of pregnancy is now an accepted method of termination of pregnancy. We present an uncontrolled case series of women given three oral doses of misoprostol for the treatment of incomplete and missed abortion. We conducted a randomized prospective study of 110 pregnant women between 6 and 13 weeks with incomplete abortion, and between 6 and 20 weeks with missed abortion. Post therapy clinical evaluation were conducted 103 of 110 women 93.6 % had complete uterine evacuation without the need for surgical evacuation. 7 of 110 women ended with surgical evacuation, 6.3%. In incomplete abortion group, the success rate was 8.3 %, 45 %, 85%, 93 % after 1st, 2nd, 3rd, 4th dose respectively. In missed abortion group, the success rate was 8.0 %, 44 %, 86 %, 94 % after 1^ST , 2nd , 3rd , 4th , dose respectively . So, the difference in response rate between the two groups at the end of each dose interval was not significant statistically for all intervals. Misoprostol administered as 2-4 oral doses proved to be effective in terminating pregnancies, especially in women with early gestation. Misoprostol is a safe, effective alternative to surgical evacuation of the uterus. It is highly preferable by patients and is inexpensive.  Analogue as an alternative to surgery is acceptable to women)

, Medical abortion as an alternative to surgical abortion has many advantages since it does not require anesthetics and there is risk of cervical laceration or uterine perforation)