Correlation of serum C-reactive protein (CRP) levels and clinical outcomes in patients with COVID-19 in a tertiary care hospital
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Abstract
Background: Severe corona virus disease 2019 (COVID-19) affected patients develop multi-system organ failure, acute respiratory distress and are associated with bad prognosis and increased mortality. Prognostic biomarkers and early diagnostic to determine the risk of developing serious illness is necessary and it justify the need for our study.
Methods: In our retrospective study we analysed 72 patients with COVID-19 at the Sri Venkateshwara medical college and research centre among moderate disease groups. We analysed the importance of the potential serological inflammation indicators in predicting the severity of COVID-19 in patients using nomogram analysis, receiver operating characteristic curves, and univariate and multivariate logistic regression to understand the correlation between the serological biomarkers and duration of hospital stay.
Results: Patients with positive CRP had significantly higher (p<0.05) proportion of severe COVID19 status (97% vs 81% and 63%) on comparison patients having negative CRP. Patients with positive CRP had significantly higher (p<0.05) proportion of poor outcome (death) on comparison with patients having negative CRP.
Conclusion: CRP may be considered as potential biomarker for the prediction of severity of disease in COVID 19 patients on hospitalization.