EFFECT OF VALERIC ACID ON RAT MODEL OF ALZHEIMER’S DISEASE: A BEHAVIORAL AND HISTOPATHOLOGICAL STUDY

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the presence of neuritic plaques and neurofibrillary tangles. Aluminum has been reported to play an important role in the etiology and pathogenesis of this disease. Hence, the present study aimed to evaluate the neuroprotective role of Valeric acid on aluminum chloride (AlCl₃) induced neurobehavioral and histopathological changes in AD induced rats. AlCl₃ (100 mg/kg body weight, orally) for 42 days significantly elevated the transfer latency in Morris water maze (MWM) and also resulted in  histological disruption in the hippocampus as compared to control group. In the present study, the rats treated with Valeric acid (50mg/kg)  and its combination with the other standard drugs like Piracetam (200 mg/kg), Rivastigmine (0.5 mg/kg) showed less transfer latency on Morris Water Maze(MWM) and reversing of histological alteration. Hence, Valeric acid can be suggested as a better drug for Alzheimer’s disease.