STUDY OF CORRELATION BETWEEN LEFT VENTRICULAR DIASTOLIC DYSFUNCTION WITH HbA1C AND DURATION OF DIABETES MELLITUS”

Abstract

Diabetes Mellitus is a metabolic disease which affects various organs of the body likeheart, kidney, and peripheral nerves.Myocardial dysfunction in diabetic patients in absence of ischemic, valvular or hypertensive heart disease is identified as diabetic cardiomyopathy. It is an early sign of diabetic heart muscle involvement which usually preceeds systolic dysfunction.Studies about relationship between the glycemic control and leftventricular diastolic dysfunction are very few.    Hence this study is an attempt to determine the proportion of diastolicdysfunction in patients with type 2 DM and to correlate the relation of LVDD withHbA1c levels and duration of DM. A total of 100 diabetic patients with minimum 5 years duration of diabetes were selected from Rajarajeswari medical college and hospital. Patients with minimum history of 5 years of type 2 diabetes were evaluated for Doppler echocardiography and HbA1c levels.Results: In the present study, 58 out of 100 patients had left ventricular diastolicdysfunction and was higher prevalence in HbA1c more than 8%. Patients who had diastolic dysfunction had diabetes duration of diabetes was more than 8 years.   Conclusion: LVDD is strongly correlated with HbA1c levels and duration of diabetes mellitus. There was significant positive correlation of age, fasting blood sugars, cholesterol levels and triglyceride levels with LVDD.