EVALUATION OF ANTIDIABETIC POTENTIAL OF HYDROALCOHOLIC LEAVES EXTRACT OF CORDIA SINENSIS PLANT

Abstract

ABSTRACT

To investigate antidiabetic activity of hydroalcoholic extract of leaves of Cordia sinensis in Wistar rats.  Leaves extract of Cordia sinensis in hydroalcoholic solution were prepared by maceration method and stored. Wistar rats were made diabetic by a single dose of 'Alloxan monohydrate'. Hydroalcoholic leaves extract of Cordia sinensis  was screened for antidiabetic activity and given to the 'Alloxan monohydrate'-induced diabetic rats at a concentration of 100 mg/kg and 200 mg/kg of body weight in different groups of 6 diabetic rats each orally once a day for 15 days. Glibenclamide is  given to another group to support the result at a dose of 600µg/kg p.o of body weight orally once a day for 15 days. Blood glucose levels and body weights of rats were measured on 0, 7^th, and 15^th days.  Oral administration of the extracts for 15^th days caused a significant (P < 0.01) reduction in blood glucose levels in diabetic rats. The body weight of diabetic animals was also improved after daily administration of extracts. The extract also improved other altered biochemical parameters associated with diabetes. Also the changes in food intake, water intake, and weight of internal organs were also restored to normal by the prolonged effect of extract treatment.

Keyword: Cordia sinensis, Glibenclamide, Alloxan monohydrate