Imaging of Primary Neuroendocrine Breast Carcinoma About Three Clinical Cases and Review of the Literature.

Abstract

The article reports three cases of primary breast neuroendocrine tumor, which is a rare form of breast cancer, derived from neuroendocrine cells. The three patients, aged 53, 51 and 47 years respectively, had no family or personal history of breast and ovarian cancer. Imaging showed variable appearances: the first case was an irregular mass, without microcalcifications and the second case the mass was lobulated, with microcalcifications having 18F-FDG uptake. The third was irregular in shape and contours. The diagnosis was confirmed by biopsy, which revealed the expression of neuroendocrine markers such as chromogranin A and synaptophysin. The patients were treated with surgery, radiotherapy and chemotherapy, with regular follow-up. The article discusses the radiological, epidemiological, clinical, histological and therapeutic characteristics of this rare entity, based on a review of the literature,

Keywords: Neuroendocrine carcinoma, breast, mammography, ultrasound, biopsy, immunohistochemistry. MRI.