Prognostic Significance of Lymphocyte to Monocyte Ratio in Ovarian Cancer: A Brief Report
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Abstract
Ovarian cancer (OC), one of the most fatal gynaecological malignancies, with late-stage diagnoses contributing to high mortality rates. Identifying reliable prognostic markers is crucial to improving patient outcomes. The LMR (lymphocyte-monocyte ratio) has gained attention as a potential biomarker in EOC (Epithelial Ovarian Cancer). This review consolidates findings from ten studies sourced from PubMed, which investigate the role of LMR in disease prognosis, survival outcomes, as well as clinical applications. The evidence indicates that a low LMR is associated significantly with minimal PFS(Progression-Free Survival) as well as OS(overall survival) in patients with OC. Additionally, LMR correlates with advanced FIGO stages, elevated CA-125 levels, and residual tumor burden post-surgery. Several studies support integrating LMR into clinical decision-making to enhance prognostic stratification and improve therapeutic strategies. Future research should focus on prospective validation and standardization of LMR thresholds for clinical use.
Keywords: Lymphocyte-to-Monocyte Ratio, Ovarian Cancer, CA-125, Survival Analysis
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