Relation between Postprandial Triglycerides and Coronary Artery Disease severity

Abstract

Background: The main cause of cardiovascular disease, atherosclerosis, is more likely to occur in those with elevated serum triglyceride concentrations. Compared to fasting triglycerides, postprandial triglyceride concentrations have been demonstrated to be a more reliable indicator of cardiovascular disease. Objective: The study was aimed to study the relation between  postprandial triglyceride and coronary artery disease severity. Patients and methods: The current study included one hundred and twenty individuals presented to Cardiology Department, Al Bayda Medical Center, Omar Elmokhtar University  within a time period of six months from December 2023 to May 2024, Inclusion criteria includes CAD based on coronary angiography (CA). The patients was subjected to complete history taking,clinical examination and investigation of fasting and postprandial lipids profile. Results: ischemic heart disease was statistically higher in group III versus group II  and there was high statistically significant difference between the all studied groups regarding chest pain. There was a high statistical difference between all groups regarding fasting TG, fasting cholesterol, fasting LDL and  fasting HDL. There high statistical difference between all groups in Post prandial  TG, Post prandial cholesterol and Post prandial LDL. there was a high statistical significant difference between all studied groups in the severity of CA according to syntax score. Conclusions: There is statistically a significant correlation between postprandial Triglyceride and coronary artery disease even in patients having normal fasting triglyceride level. It means that patients having high postprandial triglyceride levels have a higher risk of coronary artery disease and severity could be a future target in managing CAD patients.

Keywords: Triglycerides, Atherosclerosis, Coronary artery disease (CAD), Postprandial triglyceride, Fasting triglyceride